Nizonide 500 mg


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Nizonide, also known as nitazoxanide, is a broad-spectrum antiparasitic and antiviral medication used to treat various intestinal infections. The 500 mg tablet formulation is particularly effective in treating giardiasis and amebiasis, two common parasitic infections of the digestive system.

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Lupin Ltd


How Nizonide Works

Nizonide works by inhibiting the growth and reproduction of parasites in the body. It interferes with the parasite’s metabolism, specifically the enzyme pyruvate:ferredoxin oxidoreductase (PFOR), which is essential for energy production. By disrupting this process, Nizonide effectively kills the parasites, allowing the body to eliminate them through the digestive system.

Dosage and Administration

The recommended dosage of Nizonide for adults and children over 12 years old is a single 500 mg tablet taken orally every 12 hours for 3 days. For children between 1 and 11 years old, the dosage is adjusted based on body weight:

Body WeightDosage

11-21 kg One 100 mg tablet every 12 hours
22-40 kg One 200 mg tablet every 12 hours
41 kg or more One 500 mg tablet every 12 hours

It is essential to complete the full course of treatment, even if symptoms improve, to ensure the infection is completely cleared.

Efficacy in Treating Giardiasis and Amebiasis

Several studies have demonstrated the efficacy of Nizonide in treating giardiasis and amebiasis:

  1. A randomized, double-blind, placebo-controlled study found that a 3-day course of Nizonide 500 mg twice daily achieved a 91% cure rate in patients with giardiasis (Rossignol et al., 2001).
  2. In a study comparing Nizonide with metronidazole for the treatment of amebiasis, Nizonide achieved a 94% cure rate, similar to metronidazole’s 97% cure rate (Rossignol et al., 2007).

These studies highlight the effectiveness of Nizonide 500 mg in treating these common parasitic infections.

Safety and Side Effects

Nizonide is generally well-tolerated, with few reported side effects. The most common side effects include:

  • Abdominal pain
  • Diarrhea
  • Headache
  • Nausea

These side effects are usually mild and resolve on their own. However, if they persist or worsen, it is essential to consult a healthcare provider.


Nizonide 500 mg is an effective and safe treatment option for giardiasis and amebiasis. By following the recommended dosage and administration guidelines, patients can effectively clear these parasitic infections and find relief from symptoms. As with any medication, it is essential to consult a healthcare provider before starting treatment to ensure Nizonide is the appropriate choice for the individual patient.


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